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If you have diabetes, monitor your blood sugar carefully if you are taking DHEA.

Do not use DHEA if you are pregnant or breast-feeding.ĭiabetes: DHEA can affect how insulin works in the body. It can cause higher than normal levels of a male hormone called androgen. Pregnancy and breast-feeding: DHEA is possibly unsafe when taken during pregnancy or breast-feeding. DHEA vaginal inserts have been safely used for up to 3 months.

When applied into the vagina: DHEA is possibly safe when used appropriately. DHEA cream has been used safely for up to 1 year. When applied to the skin: DHEA is possibly safe when used appropriately. Using higher doses or using it long-term can increase the risk of serious side effects including cancer. Do not use DHEA in doses higher than 50-100 mg daily or for a long period of time. DHEA is possibly unsafe when used in high doses or long-term. DHEA side effects are usually mild and might include acne and upset stomach. DHEA has been used safely for up to 2 years, usually in doses of 50 mg daily. When taken by mouth: DHEA is possibly safe when used short-term.